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Genes down- and up-regulated in Parp-1 -/- livers
Genes down- and up-regulated in Parp-1 -/- livers
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Genes down-regulated in Parp-1 -/- ES cells
Genes down-regulated in Parp-1 -/- ES cells
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Differential expression of genes between Parp-1 +/+ and Parp-1 -/- ES cells,...
Differential expression of genes between Parp-1 +/+ and Parp-1 -/- ES cells, livers, and EFs
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Semi-quantitative RT-PCR analysis of H19 and other extraembryonic marker...
Semi-quantitative RT-PCR analysis of H19 and other extraembryonic marker gene expression in undifferentiatiated ES cells (A) or during differentiation of ES cells after LIF withdrawal (B)
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Confirmation of differentially expressed genes in microarray analysis by...
Confirmation of differentially expressed genes in microarray analysis by northern blot analysis (A), and functional categorization of up- and down-regulated genes (B)
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Comparison of gene expression profiles among cell lines, animals, or cell...
Comparison of gene expression profiles among cell lines, animals, or cell types
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Effect of Parp-1 deficiency on gene expression
Effect of Parp-1 deficiency on gene expression
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Pathway analysis of 2223 significant genes using a Fisher's Exact Test...
Pathway analysis of 2223 significant genes using a Fisher's Exact Test identified the listed pathways (p
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Summary of the Z statistics for human chromosomes for each test sample from...
Summary of the Z statistics for human chromosomes for each test sample from the CGMA analysis. A Z-statistics of 1.96 corresponds to α = 0.05, or 95% confidence that the expression bias in the...
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Seven blocks of the significant genes from the rat 1q conservated across...
Seven blocks of the significant genes from the rat 1q conservated across rat, mouse and human. The log2-transformed expression of average fold change (average over four tumor samples) for each gene is...
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Genes significantly differentially expressed in rat (shown in Figure 1)...
Genes significantly differentially expressed in rat (shown in Figure 1) mapped to the orthologous genes on chromosomes of human
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Genes significantly differentially expressed in rat (shown in Figure 1)...
Genes significantly differentially expressed in rat (shown in Figure 1) mapped to the orthologous genes on chromosome of mouse
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Expressed genes in microarray mapped to the rat cytogenetic location and...
Expressed genes in microarray mapped to the rat cytogenetic location and chromosome
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Biological networks and associated top functions generated from...
Biological networks and associated top functions generated from polysome-bound probe sets regulated upon HepaRG cell differentiation
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Transcriptional, translational, and post-translational regulation of HNF1α...
Transcriptional, translational, and post-translational regulation of HNF1α and HNF4α during HepaRG cell differentiation
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Translational control associated with hepatocytic differentiation targets...
Translational control associated with hepatocytic differentiation targets specific cellular functions
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Validation of the array data by real time PCR (a) using total and...
Validation of the array data by real time PCR (a) using total and polysome-bound RNA populations and (b) using individual fractions from mRNPs and polysomal fractions separated on sucrose gradient
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Correlation between total RNA and polysome-bound RNA fold changes upon...
Correlation between total RNA and polysome-bound RNA fold changes upon HepaRG cell differentiation
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Pipeline for profiling of transcriptional and translational changes...
Pipeline for profiling of transcriptional and translational changes occurring during hepatocytic differentiation of HepaRG cells
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Scheme for the uptake and utilisation of PHE by the liver of lactating dairy...
Scheme for the uptake and utilisation of PHE by the liver of lactating dairy cows: (A) total PHE and (B) [13C] labelled PHE. The small circles in Figure indicate fows out of the system which need to...
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Fatty acid composition of the experimental diets. The sources of all oils are...
Fatty acid composition of the experimental diets. The sources of all oils are given in Table . Values represent g FA/100 g total FA, following 3 determinations. The FUNG diet contained ca. 5% AA; the...
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Dietary composition of the experimental diets. Values represent the weight...
Dietary composition of the experimental diets. Values represent the weight percent of each component in the diet, wet weight basis. Fungal oil was the source of AA; fish oil was the source of DHA....
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Ratios of FA in hepatic PL pools with a Δ9 double bond/equivalent FA without...
Ratios of FA in hepatic PL pools with a Δ9 double bond/equivalent FA without a Δ9 double bond. There was some evidence to indicate Δ9 desaturase activity may have been impaired, as explained in the...
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Ratios of FA with n +2 carbons/FA with n carbons in the diet and various...
Ratios of FA with n +2 carbons/FA with n carbons in the diet and various hepatic PL pools. There was some evidence to indicate elongase activity may have been impaired in some cases, as explained in...
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Differentially expressed genes in response to dietary LC-PUFAs in (A)...
Differentially expressed genes in response to dietary LC-PUFAs in (A) hippocampus and (B) liver. Table includes gene categories discussed in the manuscript. Genes are grouped by functional category,...
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N6/N3 LC-PUFA ratios [(20:4n6 + 22:4n6)/(20:5n3+22:5n3+22:6n3)] in whole...
N6/N3 LC-PUFA ratios [(20:4n6 + 22:4n6)/(20:5n3+22:5n3+22:6n3)] in whole brain, hippocampus, and hepatic phospholipid pools. Typically, the above ratios were highest following feeding of the...
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Venn diagrams depicting the top 10 GO functional categories in the...
Venn diagrams depicting the top 10 GO functional categories in the hippocampus and liver. Examining the top 10 GO classifications for cellular component (CC), biological process (BP), and molecular...
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Graphical representation of the trend and spread of the hepatic microarray...
Graphical representation of the trend and spread of the hepatic microarray data. Blue dots indicate the highest fold change for each probe set on the Affymetrix Mu11K chip, where the highest fold...
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CR and Keap1-KD affects expression of some RISC complex components in liver....
CR and Keap1-KD affects expression of some RISC complex components in liver. Total RNA was isolated from livers of C57BL/6 and Keap1-KD mice fed ad libitum (AL) and placed on 40% CR for 6 weeks. mRNA...
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Effect of Keap1 knockdown and targeted Nrf2 deletion on miRNA expression in...
Effect of Keap1 knockdown and targeted Nrf2 deletion on miRNA expression in mouse livers after CR. The RNA fraction enriched for small RNAs was isolated from livers of male C57BL/6 and Keap1-KD mice...
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Keap1 knockdown enhances CR-related induction of fatty acid oxidation genes...
Keap1 knockdown enhances CR-related induction of fatty acid oxidation genes and inhibition of lipogenic genes. Total RNA was isolated from livers of male C57BL/6 and Keap1-KD mice fed ad libitum (AL)...
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Keap1-KD mice gained less weight and had lower hepatic lipid content after...
Keap1-KD mice gained less weight and had lower hepatic lipid content after CR compared to C57BL/6 mice. (a) Body weight and percent body weight in C57BL/6 and Keap1-KD mice during CR. During 6 weeks...
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Sequential steps in formation of Composite AG nanoparticles.
Sequential steps in formation of Composite AG nanoparticles.
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Changes in particle size and zeta potential of AG nanoparticles (AGnp) in pH...
Changes in particle size and zeta potential of AG nanoparticles (AGnp) in pH range 2–10.
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Pixel quantitative analysis of nanoparticle localization in liver. Normal...
Pixel quantitative analysis of nanoparticle localization in liver. Normal liver after 1 h,A1,B1,C1; APAP damaged liver after 1 h A3,B3,C3; Normal liver after 3 h, A2,B2,C2; APAP damaged liver after 3...
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Nanoparticle localization in liver. Transmitted optical microscopy image of...
Nanoparticle localization in liver. Transmitted optical microscopy image of (a) normal liver and (b) APAP damaged liver. Fluorescent microscopy image; Fnp-treated (c) normal liver and (d) APAP damaged...
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Effect of APAP, AG and nanoparticles on Malonedialdehyde, Superoxide...
Effect of APAP, AG and nanoparticles on Malonedialdehyde, Superoxide Dismutase and Catalase activity in mouse liver.
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Liver Histopathology Study acquired at 40x. (a) Group 1, normal; (b) Group...
Liver Histopathology Study acquired at 40x. (a) Group 1, normal; (b) Group 2, APAP; (c) Group 3, APAP and AG; (d) Group 4, APAP and AGnp; (e) Group 5, APAP and Hep-AGnp II; (f) Group 6, APAP and...
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Nanoparticles stability studies: (a) particle size, (b) drug load.
Nanoparticles stability studies: (a) particle size, (b) drug load.
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FT IR Studies for polymers and nanoparticles. (a) FT IR spectra of a) PLGA...
FT IR Studies for polymers and nanoparticles. (a) FT IR spectra of a) PLGA (blue), b) AG (green) and c) Pluronic (brown); (b) FTIR spectra of a) Heparin (blue), b) Hep-AGnp I (green), c) Hep-AGnp II...
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Atomic force microscopy in tapping mode; (a) nanoparticle, AGnp; (b) heparin...
Atomic force microscopy in tapping mode; (a) nanoparticle, AGnp; (b) heparin functionalized nanoparticle Hep-AGnp II.
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Effects of the SNP (−11187G>A) on expression level of OATP1B1 mRNA. A...
Effects of the SNP (−11187G>A) on expression level of OATP1B1 mRNA. A comparison of OATP1B1 mRNA levels in carriers and non-carriers (wt/wt, −11187GG homozygote; wt/mut, heterozygote of −11187G and...
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Differential Increase (A) and Decrease (B) in miRNA Expression in Livers of...
Differential Increase (A) and Decrease (B) in miRNA Expression in Livers of C57BL/6 and Keap1-KD mice After CR
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Serum Biochemical Measurements after 3 week CR
Serum Biochemical Measurements after 3 week CR
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